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Additionally, long-term use of metformin is associated with vitamin B12 deficiency 2

Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population Low serum vitamin B-12 and folate concentrations and low thiamin and riboflavin intakes are inversely associated with greater adiposity in Mexican American children Serum concentrations of vitamin B-12 and folate were inversely associated with BMI

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People with a severe deficiency or absorption problems can feel the effect wear off sooner

Even though there is limited research on the effects of Vitamin B12 on your body fat, it does affect your fat metabolism